Surgery Plus Target-reduction Chemoradiotherapy vs Regular Chemoradiotherapy for Newly Diagnosed Resectable Nasopharyngeal Carcinoma

This study is comparing two treatment strategies for people with a specific type of nasopharyngeal carcinoma (cancer of the back of the nose) that can be removed surgically: one group receives surgery plus chemotherapy and radiation targeting only the remaining disease areas, while the other receives standard chemotherapy and radiation without surgery. **You may be eligible if...** - Your nasopharyngeal cancer is stage II–IVA (per AJCC 8th edition) and has been confirmed as the non-keratinizing type - Your primary tumor and lymph nodes are considered surgically removable based on pre-treatment imaging - You have adequate organ function (blood counts, liver, kidney) **You may NOT be eligible if...** - Your cancer has already spread to distant organs or is a recurrence - You have severe heart or lung problems that prevent surgery - Your tumor invades the internal carotid artery or is too close to major blood vessels - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.