Clinical Study of PSMA-targeted CAR-T Cells in the Treatment of Castration-resistant Prostate Cancer

This study is testing a new type of immune therapy called PSMA-targeted CAR-T cells — where a patient's own immune cells are modified in the lab to specifically recognize and attack prostate cancer cells — in men with castration-resistant prostate cancer (cancer that keeps growing despite hormone therapy). **You may be eligible if...** - You are a man between 18 and 75 years old - You have prostate cancer that has stopped responding to both hormone therapy (including second-generation options) and taxane chemotherapy - You have measurable or evaluable disease - Your liver, kidney, lung, and heart function are within acceptable limits **You may NOT be eligible if...** - You have active HIV, active hepatitis B or C, or active tuberculosis - Your immune cells cannot be successfully modified in the lab (insufficient for the manufacturing process) - You have significant dysfunction of major organs (heart, lung, liver, kidney) - You have another active cancer - You have a psychiatric illness that prevents cooperation with treatment - You have had severe allergic reactions, especially to IL-2 Talk to your doctor to see if this trial is right for you.