RecruitingNot ApplicableNCT05355363

Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay


Sponsor

Centre hospitalier de l'Université de Montréal (CHUM)

Enrollment

730 participants

Start Date

Feb 27, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The primary aim of this study is to determine the rate of total metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions (SL) \[sessile serrated polyps (SSPs), traditional serrated adenomas (TSAs)\], and metachronous high-risk adenoma (HRA) after index detection of high-grade dysplasia (HGD). We will use the database of patients diagnosed with SL or HGD at index colonoscopy with a delay in surveillance and determine the risk of advanced lesions (especially high-risk lesion and CRC detection) of these delayed colonoscopies. The aim is to determine the effects of breach of continuity of care in these patients.


Eligibility

Min Age: 45 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at the risk of developing new concerning findings in the colon (such as advanced polyps or cancer) in people who were overdue for their recommended follow-up colonoscopy after having certain types of polyps (called serrated lesions or high-grade dysplasia) found previously. **You may be eligible if...** - You are between 45 and 80 years old - You had a colonoscopy at the Montreal University Hospital Center between 2009 and 2022 - A serrated lesion or high-grade dysplasia polyp was found at that colonoscopy - You did not have a follow-up colonoscopy within the recommended timeframe **You may NOT be eligible if...** - You have been diagnosed with inflammatory bowel disease - You have a hereditary colorectal cancer syndrome (e.g., Lynch syndrome) - You already had colorectal cancer at the first colonoscopy - You have serrated polyposis syndrome - You have a short life expectancy and would not benefit from colonoscopy - Your follow-up is not yet overdue according to guidelines Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTStandard Colonoscopy

Standard colonoscopy: All optically diagnosed polyps will be removed and sent to the CHUM pathology laboratory for histopathological evaluation according to institutional standards.


Locations(1)

Centre Hospitalier de l'Université de Montréal

Montreal, Quebec, Canada

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NCT05355363


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