A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation
Stellate Ganglion Blockade for the Prevention of Atrial Fibrillation After Cardiac Surgery: A Randomized Placebo-Controlled Trial
Mayo Clinic
220 participants
Apr 19, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to test if a nerve block procedure called a stellate ganglion block can help decrease the chance of atrial fibrillation after surgery. Atrial fibrillation is the abnormal, fast beating of the upper chambers of the heart. Stellate ganglion blockade has shown to decrease other types of abnormal heart rhythms as well as decrease the chance of atrial fibrillation.
Eligibility
Inclusion Criteria2
- Patient presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
- Patients scheduled to undergo mitral or aortic valve surgery with or without coronary artery bypass grafting.
Exclusion Criteria10
- Patients with a history of permanent atrial fibrillation, left or right ventricular assist device implantation or explantation.
- Patients with procedures not requiring cardiopulmonary bypass.
- Patients with procedures requiring deep hypothermic circulatory arrest.
- Patients with active infection or sepsis.
- Pre-operative immunosuppressive medication use (including steroid use).
- Pre-operative anti-arrhythmic medication use (aside from beta-blockers).
- Patients with Immunodeficiency syndrome.
- Patients with known neurologic disorder.
- Patients requiring left internal jugular central line placement.
- Performance of Maze procedures or left atrial appendage ligation procedures will not exclude patients from potential enrollment as atrial fibrillation still occurs postoperatively while the scarring from the Maze procedure forms.
Interventions
Ultrasound guided injection into the stellate ganglion performed in the right side of the neck in a sterile fashion.
10 mL of 0.5% without epinephrine injected in the plane of the right stellate ganglion
10 mL of saline injected in the plane of the right stellate ganglion
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05357690