Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Multiple Myeloma (MM) Precursor Conditions

This study is investigating what biological differences distinguish people with pre-cancerous blood conditions — specifically MGUS (monoclonal gammopathy of undetermined significance) and smoldering myeloma (SMM) — who go on to develop full multiple myeloma, versus those whose condition stays stable. **You may be eligible if...** - You have been diagnosed with MGUS or smoldering multiple myeloma (SMM) according to standard 2014 criteria, confirmed by blood or urine protein tests or bone marrow biopsy - You are 18 or older - You have an acceptable health/performance status **You may NOT be eligible if...** - You have already progressed to active multiple myeloma requiring treatment - You have significant other serious medical conditions - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.