Fecal Microbiota Transplantation for Irritable Bowel Syndrome Associated Food Intolerance
Helsinki University Central Hospital
45 participants
Apr 30, 2022
INTERVENTIONAL
Conditions
Summary
Previous studies have shown that stool transplantation (FMT) have positive effect in symptoms for some patients with irritable bowel syndrome (IBS). Studies have shown that it is possible by FMT to reverse the microbiome of the recipient's intestine in the direction of the microbiome of the donor. The effect on eating habits for engraftment of microbiome by FMT is unknown. The purpose of this study is to investigate whether FMT relieves FODMAP diet extension without worsening intestinal symptoms in IBS patients.
Eligibility
Inclusion Criteria4
- Adults, age 18-75 years, knowledge of the Finnish language
- IBS patients have been diagnosed with the Rome IV- criteria, all IBS-subtypes will be accepted to the trial
- The patient must consume low FODMAP diet to control IBS symptoms
- Patient must sign the informed consent
Exclusion Criteria7
- Diagnosed allergies to food components in the study dietary protocol
- Pregnancy and breastfeeding
- Antibiotic treatment less than three months prior enrolment
- Faecal incontinence, i.e., inability to retain enema
- Abuse of drugs, alcohol or medications
- Other diagnosis besides IBS causing GI symptoms, these include IBD, microscopic colitis, coeliac disease and bile acid diarrhoea.
- Severe psychiatric or neurologic condition decreasing patient's compliance
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Interventions
FMT from healthy donor or placebo
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05361785