Bio-CAR-T BS Study

This study is testing a CAR-T cell therapy (a treatment that reprograms your own immune cells to fight cancer) for people with two types of blood cancer — B-cell acute lymphoblastic leukemia (ALL) or large B-cell lymphoma — that has returned or is not responding to treatment. The study compares different versions of this therapy. **You may be eligible if...** - You have B-cell ALL (up to age 25) or large B-cell lymphoma/primary mediastinal B-cell lymphoma (ages 18–70) - Your cancer has relapsed or failed to respond after at least 2 lines of treatment - You are in reasonably good health (ECOG 0 or 1) - Your major organ functions are acceptable - You have no active or uncontrolled infections - Your expected survival is at least 3 months **You may NOT be eligible if...** - You are outside the specified age ranges for your condition - You have had a blood clot (thromboembolism) in the last 6 months - You have serious heart, nerve, or immune system problems - You have had immunosuppressive treatment in the past 24 months for a non-cancer condition - Your life expectancy is less than 3 months Talk to your doctor to see if this trial is right for you.