Adaptive Optics Retinal Imaging

This study is using a high-resolution eye imaging technique called adaptive optics retinal imaging to photograph individual cells in the back of the eye. Researchers want to study how the retina changes in people with open-angle glaucoma (a condition where elevated eye pressure damages the optic nerve) compared to people with normal vision. **You may be eligible if...** - You are 21 or older - You can follow simple instructions and cooperate with the imaging process (similar to a routine eye exam) - You have been diagnosed with primary open-angle glaucoma (POAG) — for the glaucoma group - OR you have normal eyes and vision — for the comparison group **You may NOT be eligible if...** - You are under 21 - You have a vision condition that prevents clear imaging (such as unstable fixation or very cloudy eye media) - Your prescription is outside the range of –8 to +4 diopters - You have had a bad reaction to eye-dilating drops before - You have narrow angles or a history of acute angle-closure glaucoma - You have lung disease like COPD or asthma (for the oxygen challenge portion only) - You tested positive for COVID-19 at enrollment or have chronic light sensitivity from it Talk to your doctor to see if this trial is right for you.