RecruitingNot ApplicableNCT05371886

Pharmacokinetics-pharmacodynamics of Morphine With or Without Midazolam Administered by Continuous Infusion in Neonatal Intensive Care

Sponsor

Centre Hospitalier Intercommunal Creteil

Enrollment

180 participants

Start Date

Apr 1, 2023

Study Type

INTERVENTIONAL

Conditions

Sedation Complication Mechanical Ventilation in Neonates

Summary

This study aims to describe a dose-effect relationship of morphine alone and morphine and midazolam administered as continuous infusion in neonates hospitalized in Neonatal intensive care unit and undergoing mechanical ventilation, through PKPD modelling.

Eligibility

Min Age: 20 WeeksMax Age: 45 Weeks

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Dose-effect relationship of morphine +/- midazolam administration for people with mechanical ventilation in neonates and sedation complication. The study is currently recruiting participants at 5 locations. People eligible for this study include aged 20 Weeks to 45 Weeks.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDose-effect relationship of morphine +/- midazolam administration

Dose-effect relationship of morphine +/- midazolam administration as continuous infusion in neonates undergoing mechanical ventilation through PKPD modelling

Locations(5)

CHRU Morvan

Brest, France

CH SUD Francilien

Corbeil-Essonnes, France

CHI Créteil

Créteil, France

CHU Lille

Lille, France

CHU Tours

Tours, France

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NCT05371886

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