RecruitingPhase 2NCT05376111

Study of Venetoclax Combined With Azacitidine Regimen in Newly Diagnosed T-ALL Patients

A Prospective, Multi-Center Study to Evaluate the Efficacy and Safety of Venetoclax Combined With Azacitidine Regimen in Newly Diagnosed T-cell Acute Lymphoblastic Leukemia Patients


Sponsor

The First Affiliated Hospital of Soochow University

Enrollment

28 participants

Start Date

Apr 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the efficacy and safety of venetoclax combined with azacitidine regimen for newly diagnosed T-ALL patients.


Eligibility

Min Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of two cancer drugs — venetoclax and azacitidine — as a new treatment for patients who have just been diagnosed with a type of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL). **You may be eligible if...** - You are 15 years old or older - You have been newly diagnosed with T-ALL (a type of blood cancer affecting white blood cells) - You are reasonably well overall (able to manage most daily activities) - Your heart, lungs, liver, and kidneys are functioning adequately **You may NOT be eligible if...** - You are pregnant or breastfeeding, or not willing to use contraception - You have an uncontrolled active infection or active bleeding - You have had a stroke, blood clot, or brain bleed in the past year - You are allergic to the study drugs Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGVenetoclax, Azacitidine

Venetoclax orally once daily (100 mg d1, 200 mg d2, 400 mg d3-21); azacitidine 75 mg/m2 subcutaneously once daily on days 1-7.


Locations(1)

The First Affliated Hospital of Soochow University

Suzhou, Jiangsu, China

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NCT05376111


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