Personalized Cancer Stem Cell High-Throughput Drug Screening for Glioblastoma

This study is using drug sensitivity testing on a patient's own tumor cells — grown from tissue removed during surgery — to help identify which drugs might work best against their specific glioblastoma (a fast-growing brain cancer), and then personalizing treatment based on those results. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of glioblastoma (WHO Grade 4 brain tumor) - Your tumor is accessible for surgical removal (with the aim of removing most or all of the tumor) - You have not yet received any cancer treatment - You are in good general health (KPS score ≥70) with a life expectancy over 6 months - You do not have HIV, hepatitis B, or hepatitis C **You may NOT be eligible if...** - You have already received chemotherapy, radiation, or other systemic cancer treatments - Your overall health is too poor for surgery - You have active HIV or hepatitis B/C infection Talk to your doctor to see if this trial is right for you.