RecruitingNot ApplicableNCT05380531
Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section
Sponsor
Senthil Sadhasivam
Enrollment
600 participants
Start Date
Dec 5, 2022
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants
Eligibility
Sex: FEMALEMin Age: 18 Years
Inclusion Criteria1
- Adult women (\>18 yr) All races American Society of Anesthesiologists Classification (ASA) physical status: 1 to 3 undergoing elective Cesarean section that are willing to receive in-patient opioids.
Exclusion Criteria5
- Health conditions including uncontrolled diabetes (gestational or pre-existing) or hypertension (pre-eclampsia, eclampsia, or chronic)
- Any history of opioid misuse before or during pregnancy-per self-report and clinical notes
- Preoperative severe pain and opioid use/misuse, allergy to oxycodone
- Allergy to oxycodone
- Significant neurological disorders, liver and renal diseases
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Interventions
DIAGNOSTIC_TESTPreoperative Genotyping
Genotype based risk prediction and personalized pain management
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05380531
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