RecruitingNot ApplicableNCT05380531

Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section


Sponsor

Senthil Sadhasivam

Enrollment

700 participants

Start Date

Dec 5, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at creating a personalized pain management plan for women having a planned C-section (cesarean delivery). The goal is to use a platform that tailors opioid pain medication dosing to each patient's individual needs, in order to improve pain control and reduce the risk of opioid-related problems after surgery. You may be eligible if: - You are an adult woman (18 years or older) of any race - You are having a planned cesarean section - Your physical health classification is ASA 1, 2, or 3 - You are willing to receive opioid pain medication in the hospital after surgery You may NOT be eligible if: - You have uncontrolled diabetes (gestational or pre-existing) or high blood pressure (including pre-eclampsia or eclampsia) - You have any history of opioid misuse before or during pregnancy - You have severe pain before surgery or are using opioids preoperatively - You are allergic to oxycodone - You have significant neurological disorders, liver disease, or kidney disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTPreoperative Genotyping

Genotype based risk prediction and personalized pain management


Locations(4)

Riley Children's Hospital- Clinics / Labor and Delivery Unit

Indianapolis, Indiana, United States

Washington University Hospital

St Louis, Missouri, United States

UPMC Magee Women's Hospital

Pittsburgh, Pennsylvania, United States

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

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NCT05380531


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