RecruitingNCT05381792

Serial Gut Microbiome and Bacterial Gene Markers Changes After Endoscopic Resection of Colorectal Advanced Neoplasia

A Pilot Study to Assess Serial Gut Microbiome and a Panel of Bacterial Gene Markers (M3) Changes After Endoscopic Resection of Colorectal Advanced Neoplasia

Sponsor

Chinese University of Hong Kong

Enrollment

50 participants

Start Date

Sep 1, 2022

Study Type

OBSERVATIONAL

Conditions

Colorectal, Cancer Colorectal Neoplasms Colorectal Adenoma

Summary

The investigators hypothesize that gut microbiome composition and the four bacterial gene markers (M3) show dynamic changes after endoscopic resection of advanced neoplasia, some key bacteria are associated with restoration of gut microbiome after endoscopic resection.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria3

Subjects require endoscopic resection (e.g. endoscopic mucosal resection or endoscopic submucosal dissection) for advanced adenoma or early-stage colorectal cancer;
Aged 18-90 years old;
Written informed consent obtained.

Exclusion Criteria4

Absolute contraindications to colonoscopy (e.g. perforation, intestinal obstruction, unstable cardiopulmonary status);
Contraindications to endoscopic resection (e.g. active gastrointestinal bleeding, uninterrupted anticoagulation or dual antiplatelets);
Known pregnancy or lactation;
Advanced comorbid conditions (defined as American Society of Anesthesiologists grade 4 or above);