RecruitingNot ApplicableNCT05384769

Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer

Feasibility Study of Lung Cancer Screening Using Cell-Free DNA Liquid Biopsy at Home in High-Risk Current and Former Smokers

Sponsor

City of Hope Medical Center

Enrollment

108 participants

Start Date

Jul 29, 2022

Study Type

INTERVENTIONAL

Conditions

Lung Carcinoma

Summary

This clinical trial investigates how practical and doable (feasibility) cell-free deoxyribonucleic acid (DNA) liquid biopsy is in screening high-risk patients for lung cancer. Currently, a low dose computed tomography (CT) scan is used to screen for lung cancer, however, due to various factors, few high-risk patients are screened. Liquid biopsy utilizes technology that can detect small amounts of DNA shed by cancer cells and may be able to spot lung cancer at an earlier stage. If a positive result comes back from the liquid biopsy, a patient may be more willing to get a low dose CT (LDCT) scan, possibly confirming the biopsy's findings and thus leading to more early lung cancer detection.

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether a blood test called a liquid biopsy — which detects tiny fragments of cancer DNA floating in the bloodstream — can be used alongside standard CT scans to improve early lung cancer detection in heavy smokers who qualify for routine lung cancer screening. **You may be eligible if...** - You are between 50 and 80 years old - You have smoked the equivalent of at least 20 packs per year (e.g., 1 pack per day for 20 years), and if you quit, you stopped within the last 15 years - You have been referred for lung cancer screening counseling **You may NOT be eligible if...** - You currently have symptoms that might suggest lung cancer (such as persistent cough, coughing up blood, or unexplained weight loss) - You have had a chest CT or PET/CT scan within the last 12 months - You have been diagnosed with any cancer in the past 5 years (except certain skin cancers) - You are currently being treated for cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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