RecruitingNCT05386134

Adaptive Optics Retinal Imaging in Inherited and Acquired Retinal Disorders

Adaptive Optics Imaging in Retinal Disorders

Sponsor

The Hospital for Sick Children

Enrollment

200 participants

Start Date

Jun 13, 2022

Study Type

OBSERVATIONAL

Conditions

Genetic Disease Inherited Disease

Summary

This is a Prospective Observational study. The aim of the study is to understand the underlying photoreceptor, retinal pigment epithelium or retinal vascular aberrations in inherited and acquired retinal disorders. The study would use adaptive optics (AO) technology to assist in-vivo visualization of these retinal structures and ascertain changes from normal. Further, by using the AO imaging in patients before and after treatments, this study aims to better understand the effect of various interventions and develop AO as an outcome measure in various retinal disorders.

Eligibility

Min Age: 5 YearsMax Age: 70 Years

Inclusion Criteria6

Consent provided
Aged 5 - 70 years
Diagnosed with well documented retinal disorder
Subjects aged 5 years - 70 years with normal eye examination.
Patients with strabismus and otherwise normal visual acuity and eye examination
Patients with unilateral eye diseases such as cataract, with a normal eye exam in the fellow eye.

Exclusion Criteria8

Inability of the subject to maintain a stable position while seated
Uncontrolled nystagmus, trembling or movements of the eyes or the head
Presence of cataract or any opacity in the front of the eye that obscures retinal imaging
Any general disease such neurological disease which could affect vision and the retina.
History of previous uveitis, glaucoma, previous intra-ocular surgery or photodynamic therapy
High refractive errors (> +15D or < -15D) that cannot be corrected by the adaptive optics system.
Patients who have a history of photosensitivity or take any medicine that cause photosensitivity as a side effect
Patients who are aphakic after cataract surgery

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Interventions

DEVICEAdaptive Optics Retinal Camera

The rtx1 is a non-invasive device functions without making contact with the eye. The fundus of the patient's eye is illuminated with the IR light emitted from the illumination optical system. The device is comprised of an optoelectronic sensor (OES) that measures the optical defects, software that calculates the necessary corrections and a deformable mirror (DM) that constantly adapts its shape to restore the image's clarity. The digital camera, which is built into the instrument, receives the images and then the images are recorded in the computer hard disk. The AO image software registers and averages the captured image series in order to reduce noise and produce a final enhanced image. The rtx1 integrates AO technology in a flood illumination imaging system and enables visualizing the retina with a high transverse optical resolution of 250 line-pairs per millimeter.