RecruitingNot ApplicableNCT05391113

REward SYSTem in Autism Spectrum Disorder and Addictive Disorder

Stimuli Sociaux Et Non-sociaux Du Système De Récompense : Une Étude En IRM Chez Des Sujets Avec Trouble Du Spectre De L'autisme Et Des Sujets Avec Un Trouble Addictif À L'alimentation. - RESYSTAA

Sponsor

University Hospital, Tours

Enrollment

78 participants

Start Date

Jul 27, 2023

Study Type

INTERVENTIONAL

Conditions

Autism Spectrum Disorder

Summary

An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.

Eligibility

Min Age: 18 Years

Inclusion Criteria9

Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria)
Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES >= 18 criteria).
Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk.
For all participants:
Age greater than or equal to 18 years old
Without intellectual delay (IQ > 70).
Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator.
Free, express, informed and written consent of the participant.
Participant affiliated to a social security scheme

Exclusion Criteria8

Neuromotor disorders.
Visual disturbances not corrected or incompatible with MRI.
Known epilepsy.
Current substance use disorder with emotional distress/significant impact on functional outcome
Rare genetic syndrome.
Contraindications to MRI (other than body circumference)
For women of childbearing age: negative urine or blood pregnancy test
Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization)

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Interventions

DIAGNOSTIC_TESTMRI

an fMRI measurement of the BOLD physiological signal for sensory responses

DIAGNOSTIC_TESTEEG

These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.