RecruitingNCT05400590

Comparison of the Healing Properties on Corneal Cells of Groth Factor-enriched Plasma and Autologous Serum From Aniridia Patients


Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Enrollment

24 participants

Start Date

May 15, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Keratopathy of patients with aniridia leads to epithelial scarring disorders and a progressive clouding of the cornea linked to this abnormal healing (fibrosis). Treatment with autologous serum is usually undertaken to promote epithelial healing. However, autologous serum does not prevent the formation of fibrosis, whereas growth factor-rich plasma appears to be associated with a reduction in the in vitro expression of fibrosis markers. This study seeks to compare the in vitro healing and anti-fibrotic properties of autologous serum and growth factor rich plasma from aniridia patients and healthy controls.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of blood-derived eye drops — autologous serum (made from the patient's own blood) and growth factor-enriched plasma — for treating a serious eye surface condition called aniridia-associated keratopathy (where patients are born without an iris and develop progressive corneal damage). The study compares how well each type of eye drop helps heal corneal cells in the lab. You may be eligible if: - You have aniridia (confirmed genetically for patient group) - You weigh more than 43 kg - If you donate blood, at least 8 weeks have passed since your last blood collection - For healthy controls: you do not have aniridia, are matched by age and sex, and do not have diabetes You may NOT be eligible if: - Your blood sample is insufficient - You test positive for hepatitis B, C, or HIV - Your aniridia has not been genetically confirmed (for the patient group) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

PROCEDUREPeripheral venous blood sample

2.5% of body weight

PROCEDUREConjunctival impression

Collection of the most superficial conjunctival epithelial cells (desquamating) in a non- or minimally invasive, quick and almost painless way, for a biological analysis of ocular surface diseases. Application of a filter paper on the bulbar conjunctiva, under local anesthesia.


Locations(1)

Hôpital Fondation A. de Rothschild

Paris, France

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05400590


Related Trials