RecruitingNCT05404347

NGS in Gallbladder Cancer and Response to Treatment

Genetic Mutations and Response to Treatment in Gallbladder Cancer: A Hospital Based Cohort Study

Sponsor

Banaras Hindu University

Enrollment

100 participants

Start Date

Jan 1, 2018

Study Type

OBSERVATIONAL

Conditions

Gallbladder Cancer

Summary

Evidence suggests distinct models of molecular and pathologic progression, and a growing body of genetics data points to a heterogeneous collection of underlying mutations in key oncogenes and tumor suppressor genes. Although tumor genetics have been used to tailor individual treatment regimens and guide clinical decision making in other cancers, these principles have not been applied in gallbladder malignancy. Recent clinical trials with targeted therapies seem promising, although the relationships between subsets of patients with positive responses to therapy and tumor genetics remain unexplored.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is using advanced genetic testing (called next-generation sequencing or NGS) to analyze the specific gene mutations inside gallbladder cancer tumors. The goal is to identify patterns that predict how well different treatments work, which could help doctors personalize therapy for each patient. **You may be eligible if...** - You have been diagnosed with gallbladder cancer confirmed by a tissue biopsy (histological proof) - You have not yet received any cancer treatment (you are treatment-naïve) - You are willing to provide tumor tissue for genetic analysis **You may NOT be eligible if...** - Your cancer diagnosis has not been confirmed by biopsy or pathology - You are pregnant or breastfeeding - You have already started treatment for gallbladder cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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