Neoadjuvant Intense Endocrine Therapy for High Risk and Locally Advanced Prostate Cancer

This study is testing whether giving intensive hormone-blocking treatment before surgery (prostatectomy) can improve outcomes for men with high-risk or locally advanced prostate cancer. The idea is to shrink the cancer before removing it surgically. **You may be eligible if...** - You have been diagnosed with prostate cancer confirmed by biopsy - You are a candidate for radical prostatectomy (surgical removal of the prostate) - Your cancer meets high-risk criteria: tumor has spread beyond the prostate on imaging, Gleason score of 8 or higher, PSA level of 20 or higher, or lymph node involvement - You are in good physical condition (ECOG score 0 or 1) **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have poor kidney, liver, or blood function Talk to your doctor to see if this trial is right for you.