Basal Plasma Lithium Levels and Suicidal Events
Basal Plasma Lithium Levels and Suicidal Events (LIPS)
University Hospital, Montpellier
158 participants
Dec 9, 2022
OBSERVATIONAL
Conditions
Summary
Suicidal behavior is a major public health issue and there are currently no specific treatments for it. However, lithium, the reference treatment for bipolar disorder, have been shown to be effective in preventing suicidal risk. Apart from drug treatments, lithium is present in our environment and its levels varies from one individual to another, depending, especially, on diet. Knowing that patients with a mood disorder generally have a poor lifestyle and a less rich and varied diet than the general population, variations in basal lithium levels can be expected in these patients.
Eligibility
Inclusion Criteria5
- years old or over
- Current major depressive episode according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria
- No lithium-based treatment over the last 12 months
- For suicide attempters/ideations only : suicidal event over the last 12 months
- For affective controls only : no suicidal event over the last 12 months
Exclusion Criteria7
- Lifetime diagnosis of schizoaffective disorder, schizophrenia or psychosis
- Pregnancy or breastfeeding
- Deprivation of freedom (by judicial or administrative decision)
- Legal protection measure (guardianship or curators)
- Inability to understand experimental procedures
- No affiliation to the French National Social Security System
- No consent to participate in the study
Interventions
Blood sample for the determination of plasma lithium levels
Locations(1)
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NCT05409794