RecruitingPhase 1NCT05410717

CLDN6/GPC3/Mesothelin/AXL-CAR-NK Cell Therapy for Advanced Solid Tumors

Phase I Trial to Evaluate Safety and Preliminary Efficacy of CLDN6/GPC3/Mesothelin/AXL-CAR-NK in Patients With CLDN6/GPC3/Mesothelin/AXL-positive Advanced Solid Tumors


Sponsor

Second Affiliated Hospital of Guangzhou Medical University

Enrollment

200 participants

Start Date

Jun 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This study is an open, exploratory clinical study to evaluate the safety and preliminary efficacy of Claudin6, GPC3, Mesothelin, or AXL targeting CAR-NK cells in patients with Claudin6, GPC3, Mesothelin, or AXL-positive advanced solid tumors (ovarian cancer and others)


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a type of personalized cell therapy (CAR-NK cell therapy) for people with advanced solid tumors, including ovarian cancer and other cancers. The therapy uses a patient's own immune cells (NK cells), which are modified in the lab to attack cancer cells expressing specific proteins. **You may be eligible if...** - You have advanced ovarian cancer or another cancer that expresses certain proteins (Claudin 6, GPC3, Mesothelin, or AXL) - Your expected survival is more than 12 weeks - Your heart, lungs, liver, and kidneys are functioning adequately - Lab testing confirms your modified immune cells meet activity thresholds **You may NOT be eligible if...** - Your tumor does not express the required target proteins - Your cancer cells cannot be detected or targeted by the engineered immune cells - You have had certain previous treatments that interfere Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALClaudin6, GPC3, Mesothelin, or AXL targeting CAR-NK cells

Engineering Claudin6, GPC3, Mesothelin, or AXL targeting CAR combined with/or without IL7/CCL19 and/or scfv against PD1/CTLA4/Lag3 secreting vector into NK cells, which are isolated from patients with advanced ovarian cancer or other cancers with expression of Claudin6, GPC3, Mesothelin, or AXL, and then transfusing them back the patients. In some cases, the CAR-NK cells will be combined with CBD or NAD to enhance the therapeutic efficacy.


Locations(1)

The Second Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

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NCT05410717


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