A Study Comparing Perioperative Stress Reduction vs. Standard of Care in Ovarian Cancer (PRESERVE)

This study (PRESERVE) is testing whether giving stress-reducing medications — a beta-blocker to reduce the body's adrenaline response and a COX-2 inhibitor to reduce inflammation — before and during ovarian cancer surgery can improve long-term cancer outcomes by reducing the stress hormones triggered by surgery that may help cancer spread. **You may be eligible if:** - You have Stage II–IV epithelial ovarian, fallopian tube, or primary peritoneal cancer - You are scheduled for open surgery (laparotomy) with at least 10 days lead time before the procedure - You are at least 18 years old - Your overall health is acceptable for surgery (ASA score 1–3) **You may NOT be eligible if:** - You are already taking beta-blockers or COX inhibitors regularly - You have asthma, heart block, slow heart rate, right-sided heart failure, or peripheral vascular disease (contraindications to beta-blockers) - You have kidney failure, significant liver disease, or active stomach ulcers (contraindications to COX-2 inhibitors) - You have a chronic autoimmune disease or active infection - You are pregnant - Your surgery is minimally invasive (laparoscopic) Talk to your doctor to see if this trial is right for you.