A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

This study is testing whether naproxen (a common anti-inflammatory painkiller) or aspirin can help prevent cancer from developing in people with Lynch syndrome — an inherited condition that significantly raises the risk of colon, uterine, and other cancers. **You may be eligible if...** - You have been diagnosed with Lynch syndrome (carrying a mutation in a mismatch repair gene: MLH1, MSH2, EPCAM, MSH6, or PMS2) - Or you have had a Lynch-syndrome-related precancerous polyp or cancer that was confirmed through special testing **You may NOT be eligible if...** - You cannot take naproxen or aspirin (e.g., due to stomach ulcers, kidney problems, or allergies) - You have active cancer requiring other treatment - You have other conditions that make taking these medications unsafe Talk to your doctor to see if this trial is right for you.