RecruitingPhase 1NCT05412290

Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphoma

A Pilot Study Evaluating the Safety and Efficacy of Mosunetuzumab Consolidation Therapy After Autologous Stem Cell Transplantation in Patients With Relapsed/Refractory Aggressive B Cell Lymphoma


Sponsor

Washington University School of Medicine

Enrollment

15 participants

Start Date

Dec 22, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This phase 1 pilot study examines the feasibility and safety of mosunetuzumab after autologous stem cell transplant for patients with aggressive B cell lymphomas. Mosunetuzumab is an antibody that has been engineered to attach to two target cells in the immune system: T cells that normally perform tasks like killing virus-infected cells, and cancerous B cells. Mosunetuzumab has been designed to direct these T cells to kill the cancerous B cells instead.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether mosunetuzumab — a drug that helps the immune system attack lymphoma cells — given after a stem cell transplant can help prevent relapsed or treatment-resistant aggressive B-cell lymphoma from coming back. **You may be eligible if...** - You are 18 or older - You have been diagnosed with relapsed or refractory aggressive B-cell lymphoma (including large B-cell lymphoma, follicular lymphoma grade 3B, or similar types) - You are planning to undergo an autologous stem cell transplant (using your own cells) after receiving two or more prior treatment regimens - Your general health is good (ECOG score 0–2) **You may NOT be eligible if...** - You have not had a stem cell transplant - You are pregnant or unwilling to use contraception - You have certain active infections or other serious health conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGMosunetuzumab

Mosunetuzumab is administered intravenously in a "step-up" dosing strategy. The doses will be 1 mg on C1D1, 2 mg on C1D8, 60 mg on C1D15, 60 mg on C2D1, and 30 mg for all doses following.


Locations(1)

Washington University School of Medicine

St Louis, Missouri, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05412290


Related Trials