RecruitingPhase 2NCT05412589

mFOLFOX7 Plus Camrelizumab and Apatinib for Advanced HCC

Intravenous mFOLFOX7 Plus Camrelizumab and Apatinib for CNLC Stage III Hepatocellular Carcinoma


Sponsor

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Enrollment

35 participants

Start Date

Jun 10, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a prospective, one-arm, phase II clinical study of intravenous mFOLFOX6 plus Camrelizumab combined with apatinib for CNLC stage III hepatocellular carcinoma


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining mFOLFOX7 chemotherapy with camrelizumab (an immunotherapy) and apatinib (a targeted anti-cancer drug) works as a first-line treatment for people with advanced liver cancer (HCC) that is at stage III. This is a more intensive combination approach than standard treatments. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with stage III primary liver cancer (HCC) according to Chinese liver cancer staging - You have not yet received any first-line drug treatment (such as sorafenib) - You have at least one measurable tumor on imaging - Your liver function is Grade A or B (Child-Pugh scale) **You may NOT be eligible if...** - You have already started first-line treatment - Your cancer has spread beyond the liver to distant organs - Your liver or overall health is too poor to tolerate chemotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGmFOLFOX7+Camrelizumab+Apatinib

Drug: Leucovorin 200mg/m2 administered IV on Days 1 of a 21 day cycle Drug: Oxaliplatin 85 mg/m2 IV on Days 1 of a 21 day cycle. Drug: Fluorouracil 5-FU continuous infusion: 400mg/m2 on D1 and then 2400mg/m2 for 46h of each 21 day cycle. Drug: Camrelizumab 200mg infusion on D1 for every 21 days Drug: Apatinib 250mg,po,qd for every 21 days


Locations(1)

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

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NCT05412589