RecruitingNot ApplicableNCT05412771

Evolutive and Functional Bases of Menstruation in Women - 2

Bases Évolutives Et Fonctionnelles De La Menstruation Chez Les Femmes - 2

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Enrollment

20 participants

Start Date

Nov 23, 2022

Study Type

INTERVENTIONAL

Conditions

Menstruation

Summary

Menstruation corresponds to the shedding of the uterine lining when fecundation has not occurred. This is a recent evolutionary innovation in primates, and the cellular and genetic changes that led to the acquisition of menstruation are not well understood. Additionally, the uterine lining is poorly characterized in humans across the menstrual cycle, which hinders both evolutionary and medically-relevant analyses. In this study, the research team are collecting uterine endometrial tissue samples from female donors undergoing uterine surgery for benign conditions, to profile gene expression and gene regulatory elements in the major cell types that compose the uterine lining during the secretive phase of the menstrual cycle. The investigators will compare this data to similar samples collected from other primates at the same time point in the female hormonal cycle. The objective is to identify genes that have acquired novel regulation and/or expression patterns and which may be involved in menstruation, as well as better characterize the cellular and molecular pathways at work in the uterine lining of women for translational medicine purposes.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 50 Years

Inclusion Criteria8

Be between 18 and 50 years old.
Have mensturation at the time of their participation
Have given their written consent
Have an indication for surgery of hysteroscopy for removal of a polyp and/or fibroid and/or endometrial, endometrialctomy for presumed benign pathology and/or management of a uterine malformation, scheduled between days 21 and 25 of their menstrual cycle
Covered by social security
Women who have not given written consent
Women who are breastfeeding
Women with a body mass index (BMI) of less than 18.5 or more than 30

Exclusion Criteria10

Using an intrauterine device contraceptive method during the study or within the previous three months
To be Pregnant at the time of collection
Have been pregnant in the three months prior to collection
Have had amenorrhoea in the three months prior to collection
Have received hormonal treatment within the three months prior to collection
Have participated in a clinical study within 3 months prior to collection
Have a personal history of breast, ovarian, body or cervical cancer
Have a diagnosis of endometriosis
Have a diagnosis of adenomyosis
Have a diagnosis of Lynch syndrome