RecruitingNot ApplicableNCT05414045

Autologous Testicular Tissue Transplantation

Autologous Testicular Tissue Transplantation for Fertility Restoration


Sponsor

Universitair Ziekenhuis Brussel

Enrollment

5 participants

Start Date

Nov 22, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells in case of imminent gonadotoxic treatment during childhood. In case of total azoospermia or absence of spermatozoa that can be used for intra-cytoplasmic injection (ICSI) in adulthood, the investigators intend to perform the first in men autologous testicular tissue transplantation to restore fertility.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether frozen testicular tissue — collected from boys before cancer treatment that can cause infertility — can be transplanted back once they are adults to restore fertility. This is for men who had testicular tissue preserved in childhood and now wish to have biological children. **You may be eligible if...** - You are at least 18 years old - You had testicular tissue frozen (cryopreserved) before puberty as part of a fertility preservation program at the time of a cancer or blood disorder diagnosis - You now wish to become a parent - You are in a stable relationship with a female partner (cohabiting at least 1 year) - Your female partner is under 43 years old - You have had two semen analyses confirming no sperm (azoospermia) - Your cancer or blood disorder is in complete remission **You may NOT be eligible if...** - You have not reached complete remission - You are not in a relationship with a female partner - Your female partner is 43 or older - Your semen analyses show sperm is present Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREAutologous testicular tissue transplantation of prepubertal frozen testicular tissue

Freezing testicular tissue of prepubertal boys is a method for preserving spermatogonial stem cells. If no spermatozoa suitable for ICSI are detected in the ejaculate, the investigators will perform autologous testicular tissue transplantation with the primary objective being to restore spermatogenesis and fertility.


Locations(1)

UZ Brussel Centre for Reproductive Medicine

Brussels, Belgium

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NCT05414045


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