RecruitingNCT05414994
Assessment of the Ocular Microbiome in Health and Disease
Sponsor
Vanderbilt University Medical Center
Enrollment
500 participants
Start Date
Sep 7, 2023
Study Type
OBSERVATIONAL
Conditions
Summary
The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.
Eligibility
Min Age: 18 Years
Inclusion Criteria9
- We will include subjects who meet all of the following criteria:
- years of age or older
- Provide informed consent
- Cohort A - normal eyes with no ocular disease
- Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
- Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
- Cohort D - Dry AMD (age related macular degeneration)
- Cohort E - Wet AMD
- Cohort F - diabetic retinopathy
Exclusion Criteria4
- We will exclude subjects who meet all of the following criteria:
- Prior ocular disease either of the anterior or posterior segment
- Any medical comorbidities except well controlled DH and HTN
- Unable to follow up with study procedures as described
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Interventions
OTHEREye swab
This is a simple swab under the eyelids of both eyes
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05414994
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