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RecruitingNCT05414994

Assessment of the Ocular Microbiome in Health and Disease

Sponsor

Vanderbilt University Medical Center

Enrollment

500 participants

Start Date

Sep 7, 2023

Study Type

OBSERVATIONAL

Conditions

Microbial ColonizationEye DiseasesOphthalmopathy

Summary

The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment. We will conduct a prospective, observational cohort study, including a longitudinal analysis of the ocular microbiome in adults.

Eligibility

Min Age: 18 Years

Inclusion Criteria9

  • We will include subjects who meet all of the following criteria:
  • years of age or older
  • Provide informed consent
  • Cohort A - normal eyes with no ocular disease
  • Cohort B - primary open angle glaucoma/Ocular hypertension defined as mild glaucoma which is well controlled with no more than one drop of prostaglandin use daily for the past 6 months
  • Cohort C - non-infectious keratopathy not using any prescription medication (OTC artificial tears are acceptable)
  • Cohort D - Dry AMD (age related macular degeneration)
  • Cohort E - Wet AMD
  • Cohort F - diabetic retinopathy

Exclusion Criteria4

  • We will exclude subjects who meet all of the following criteria:
  • Prior ocular disease either of the anterior or posterior segment
  • Any medical comorbidities except well controlled DH and HTN
  • Unable to follow up with study procedures as described
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Interventions

OTHEREye swab

This is a simple swab under the eyelids of both eyes

Locations(1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

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NCT05414994

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