RecruitingEarly Phase 1NCT05417308

Topical or Oral Minoxidil for the Treatment of Endocrine Therapy-Induced Alopecia in Patients With Stage I-IV Breast Cancer

A Pilot Trial of Topical vs Oral Minoxidil for Treatment of Endocrine Therapy-Induced Alopecia in Breast Cancer Patients


Sponsor

Ohio State University Comprehensive Cancer Center

Enrollment

50 participants

Start Date

Mar 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This early phase I trial studies the possible benefits and/or side effects of topical or oral minoxidil in treating endocrine therapy-induced hair loss (alopecia) in patients with stage I-IV breast cancer. Endocrine therapy-induced alopecia (EIA) is a distressing side effect that leads to reduced quality of life and early cessation of therapy in women undergoing treatment for breast cancer. Patients on endocrine therapy commonly report hair loss or thinning. Minoxidil is a drug that may promote hair growth and reduce hair loss. Oral minoxidil may increase hair density in women with EIA, and work the same as topical minoxidil in treating EIA in patients with breast cancer.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether topical (applied to the scalp) or oral minoxidil can help with hair loss in women with breast cancer who are taking hormone-blocking therapies like tamoxifen or aromatase inhibitors. Hair thinning is a distressing side effect that many women experience on these long-term treatments. **You may be eligible if...** - You are a woman aged 18 or older - You have been diagnosed with breast cancer (any stage) - You are currently taking tamoxifen or an aromatase inhibitor (with or without ovarian suppression) - You have noticed hair loss since starting endocrine therapy **You may NOT be eligible if...** - You have known hair loss from other causes (like thyroid disease or alopecia areata) - You are currently using other treatments for hair loss - You have significant heart or kidney problems - You are pregnant or breastfeeding - You have an allergy to minoxidil Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMinoxidil

Applied topically

DRUGMinoxidil

Given PO

OTHERQuality-of-Life Assessment

Ancillary studies

OTHERQuestionnaire Administration

Ancillary studies


Locations(1)

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

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NCT05417308


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