RecruitingNot ApplicableNCT05423275

Light and Ion Maintenance In Treatment for Depression (LIMIT-D): Feasibility Study


Sponsor

University of British Columbia

Enrollment

100 participants

Start Date

Mar 13, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Antidepressants are widely used as first-line treatments for major depressive disorder (MDD). Clinical guidelines recommend 6-24 months of "maintenance" antidepressant treatment, after patients achieve symptom remission, to prevent relapse but many people stop antidepressants too soon relapse into another depressive episode. We will test non-medication treatments, negative ion therapy and light therapy, to see they can substitute for antidepressants to prevent relapse. This is a "feasibility" study to see if participants use study treatments properly, before doing a larger, definitive trial. In this 28-week study, 100 participants with MDD who are in remission with antidepressants will be treated with light therapy or negative ion therapy (with half of devices active and half inactive) while slowly discontinuing the antidepressant, and monitored for relapse.


Eligibility

Min Age: 19 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is exploring whether light therapy and a dietary supplement called lithium orotate can help people with depression stay well after they stop taking antidepressants. It is a feasibility study, meaning researchers are first checking whether this approach is practical and acceptable before running a larger trial. **You may be eligible if:** - You have a diagnosis of major depressive disorder (MDD) - You are currently taking a standard antidepressant at an approved dose (unchanged for at least a month) - You want to stop your antidepressant (for example, due to side effects) - Your depression is in remission (low symptom scores on a clinical scale at two visits) - You are comfortable completing English or French surveys **You may NOT be eligible if:** - You have a primary diagnosis other than MDD (e.g., bipolar disorder, personality disorder) - You have seasonal affective disorder or psychotic depression - You are at high risk for suicide - You have a significant alcohol or substance use problem in the past 6 months - You have a serious neurological condition or unstable medical illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICENegative ion therapy

Negative ion generator

DEVICELight therapy

Fluorescent light box


Locations(1)

Djavad Mowafaghian Centre for Brain Health

Vancouver, British Columbia, Canada

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NCT05423275