RecruitingNot ApplicableNCT05424302

Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy

Effect of Peripheral Vestibular Pathology Location on the Ability of Home-based Virtual Reality to Improve Symptoms of Peripheral Vestibular Disorders

Sponsor

University of British Columbia

Enrollment

50 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Benign Paroxysmal Positional Vertigo Meniere Disease Peripheral Vestibular Disorder Vestibular Neuritis Vestibular Neuronitis Labyrinthitis Herpes Zoster Oticus

Summary

This parallel-group randomized controlled trial aims to determine if the location of the lesion(s) in the vestibular system (unilateral versus bilateral, lateral semi-circular canal versus otolith) impacts the effectiveness of adjunct take-home head-mounted display (HMD) virtual reality (VR) therapy in improving patient symptomatology. Fifty patients meeting inclusion criteria will be recruited from the principal investigator's neurotology clinic. Baseline symptomatology questionnaires will be completed, followed by random allocation to virtual reality and control groups. Vestibular rehabilitation and virtual reality protocols will be adhered to for 4 to 8 weeks, followed by symptomatology questionnaires. Data analysis will be conducted to answer the study's objectives.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Participants diagnosed with chronic (≥3 months) unilateral or bilateral peripheral vestibular disorders such as vestibular neuritis, labyrinthitis, Ramsay Hunt syndrome, ischemic lesion and trauma.
Diagnosis made using caloric testing (≥25% reduced vestibular response) and either ocular vestibular evoked myogenic potential (oVEMP) or cervical vestibular evoked myogenic potential (cVEMP) testing.
Participants prescribed vestibular rehabilitation
Participants ≥18 years of age
Access to an android or iOS smart phone

Exclusion Criteria2

Pregnant participants
Participant diagnosed with a central vestibular disorder

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Interventions

BEHAVIORALStandard Vestibular Rehabilitation with Adjunct At Home Virtual Reality Vestibular Rehabilitation

The virtual reality intervention will involve standard vestibular rehabilitation as described above and adjunct at home virtual reality video game. This video game will be projected on an android or apple device accommodated into a VR headset for 20 minutes daily until the vestibular rehabilitation is complete. This video will be congruent to current vestibular rehabilitation program exercises. Point-of-view games compatible with both Android and iOS devices will be evaluated by professionals to determine the game that is most representative of current evidence based exercises.

BEHAVIORALStandard Vestibular Rehabilitation with Adjunct Auditory Intervention

The control intervention will involve standard vestibular rehabilitation as described above and adjunct audio intervention while wearing the VR headset for 20 minutes daily until the vestibular rehabilitation is complete.