RecruitingNot ApplicableNCT05426408

Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3

Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction with Nonobstructive Coronary Arteries


Sponsor

Karolinska Institutet

Enrollment

85 participants

Start Date

Nov 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.


Eligibility

Min Age: 35 YearsMax Age: 79 Years

Inclusion Criteria3

  • a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50%
  • age 35-80 years
  • reading and writing proficiency in Swedish

Exclusion Criteria9

  • Claustrofobia
  • Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)
  • Asthma or severe chronic obstructive lung disease
  • eGFR < 30 ml/min
  • spontaneous coronary artery dissection
  • acute pulmonary embolism
  • acute myocardial infarction type 2
  • cardiomyopathy other than takotsubo syndrome
  • a previous myocardial infarction due to CAD

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Interventions

DIAGNOSTIC_TESTCardiac magnetic resonance imaging to study coronary microvascular dysfunction

Myocardial perfusion mapping will be investigated after administration of adenosine


Locations(1)

Per Tornvall

Stockholm, Sweden

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NCT05426408


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