RecruitingNot ApplicableNCT05427071

Magnetic Marker Localization for Occult Breast Cancer and Target Axillary Dissection in Node-positive Breast Cancer Post-neoadjuvant Chemotherapy


Sponsor

The University of Hong Kong

Enrollment

30 participants

Start Date

Oct 15, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The use of neoadjuvant chemotherapy in breast cancer is expanding in the recent decade. Patients with good response to neoadjuvant chemotherapy could benefit from de-escalation of breast and axilla operation. However, breast tumor and involved axillary lymph node should be marked before the commencement of chemotherapy. This could facilitate subsequent operative planning and intraoperative assessment of disease response. This study aims to evaluate the feasibility of magnetic marker localization for non-palpable breast cancer and targeted axillary dissection in patients with node-positive breast cancer following neoadjuvant therapy


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the use of a tiny magnetic marker (instead of wire localization) to precisely locate and surgically remove breast cancer tumors and lymph nodes that cannot be felt by hand after chemotherapy treatment before surgery. **You may be eligible if:** - You have invasive breast cancer in the breast and 1–3 nearby lymph nodes (cT1-3N1 staging) - You are planned to receive chemotherapy before surgery (neoadjuvant chemotherapy) - You are mentally able to give informed consent - You are interested in breast-conserving surgery and targeted lymph node removal **You may NOT be eligible if:** - Your cancer has spread to distant organs, involves multiple areas of the breast, or is inflammatory breast cancer - You have had previous surgery or radiation to the same armpit - You have an allergy to dextran or iron compounds - You have an iron storage disorder - You are pregnant or breastfeeding - You have a pacemaker or metal implants in your chest or shoulder Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEMagnetic seed localization

Magnetic seed guided localization


Locations(1)

University of Hong Kong

Hong Kong, Hong Kong

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NCT05427071


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