Pilot Trial for Treatment of Recurrent Glioblastoma

This study is testing a new treatment approach for people with glioblastoma (an aggressive brain tumor) that has come back after initial treatment. The trial uses a combination of therapies delivered at the time of repeat surgery, aiming to slow the cancer's return. **You may be eligible if:** - You are 18 or older - You have a confirmed glioblastoma (IDH-wild type) that has come back for the first or second time after radiation and chemotherapy - Your tumor can be surgically removed - You are in reasonably good physical health (able to carry out daily activities) - Women who could become pregnant must have a negative pregnancy test **You may NOT be eligible if:** - Your tumor cannot be safely removed with surgery - You are not healthy enough for surgery - You have other conditions that exclude study participation Talk to your doctor to see if this trial is right for you.