RecruitingNCT05444283
Genomic Predictors of Recurrent Pregnancy Loss
Large Scale Genome Sequencing and Integrative Analyses to Define Genomic Predictors of Recurrent Pregnancy Loss
Sponsor
Yale University
Enrollment
500 participants
Start Date
Sep 1, 2021
Study Type
OBSERVATIONAL
Conditions
Summary
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.
Eligibility
Min Age: 18 YearsMax Age: 50 Years
Inclusion Criteria5
- Cohort A - Fetal Intolerome Cohort
- Women with loss of a current singleton pregnancy at < 20 0/7 weeks gestation, documented by ultrasonography or histopathological examination
- History of one or more prior pregnancy losses
- Euploid current pregnancy confirmed by karyotype, microarray, or STORK (Short-read Transpore Rapid Karyotyping) sequencing Note: A limited number of aneuploid losses will be included as part of the pilot phase
- \- Women with a history of three or more pregnancy losses of unknown cause, with or without a liveborn child
Exclusion Criteria9
- History of parental karyotype abnormalities
- History of antiphospholipid antibody syndrome
- Evidence of uncontrolled diabetes
- Evidence of uncontrolled thyroid disease
- History of autoimmune disease related to pregnancy loss (e.g., systemic lupus erythematosus, rheumatoid arthritis)
- History of uterine anomalies
- History of cervical insufficiency
- Cohort B - Maternal Effect Gene Cohort
- \- Known etiology for pregnancy loss
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Locations(10)
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NCT05444283
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