First-in-human, Study of MATTISSE® Tissue Engineering Chamber in Adult Female Patients Undergoing Breast Reconstruction After Mastectomy for Cancer

This study is testing a new tissue engineering device called MATTISSE — a chamber implanted under the skin that uses your body's own healing process to grow new breast tissue — for women reconstructing a breast after mastectomy. It's an alternative to implants or tissue flap surgery. **You may be eligible if...** - You are female and over 18 years old - You have had or will have a mastectomy for early-stage breast cancer or as a preventive measure - You need or want breast reconstruction on one side - You are having immediate or delayed reconstruction **You may NOT be eligible if...** - You need reconstruction on both breasts - You have had prior radiation to the chest wall (in some cases) - You have conditions that affect wound healing (e.g., uncontrolled diabetes) - You smoke heavily Talk to your doctor to see if this trial is right for you.