RecruitingPhase 1Phase 2NCT05463263

A Phase 1/2 Study of STP938 for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas

An Open-Label, First in Human, Phase 1/2 to Evaluate Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of the CTPS1 Inhibitor STP938 In Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas


Sponsor

Step Pharma, SAS

Enrollment

180 participants

Start Date

Aug 3, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The Phase 1 part of the study is a dose escalation of STP938 as monotherapy. The Phase 2 part of the study is cohort expansion of STP938 as a monotherapy in 5 different B and T cell lymphomas.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called STP938 in adults with B-cell or T-cell lymphoma that has returned or not responded to at least 2 prior treatments. The drug targets a pathway that helps cancer cells survive, and researchers want to find the right dose and see how well it works. **You may be eligible if...** - You are 18 or older with confirmed B-cell or T-cell lymphoma - Your lymphoma has returned or not responded to at least 2 prior treatment regimens - No standard treatments are available or appropriate for you - Your overall health is adequate for treatment **You may NOT be eligible if...** - You have untreated brain lymphoma - You have serious heart or organ problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSTP938

Small molecule


Locations(15)

Colorado Blood Cancer Institute

Denver, Colorado, United States

Florida Cancer Specialists

Sarasota, Florida, United States

Memorial Sloan Kettering

New York, New York, United States

Hôpital Saint-Louis

Paris, Paris, France

The Centre Léon Bérard

Lyon, France

Institut Paoli Calmettes

Marseille, France

CHU de Nantes

Nantes, France

Institut Gustave Roussy

Villejuif, France

University Hospitals of Leicester NHS Trust

Leicester, United Kingdom

Imperial College / Clinical Trials Unit, Hammersmith Hospital

London, United Kingdom

The Christie

Manchester, United Kingdom

Nottingham City Hospital

Nottingham, United Kingdom

Churchill Hospital

Oxford, United Kingdom

Derriford Hospital

Plymouth, United Kingdom

The Royal Marsden

Sutton, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT05463263


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