Lung Nodule Detection Using Ultra-long FOV PET/CT
Ultra-long Field-Of-View Positron Emission Tomography for Characterization of Indeterminate Lung Nodules: a Pilot Study Exploring Opportunities for Clinical Research
University Medical Center Groningen
20 participants
Jul 13, 2022
INTERVENTIONAL
Conditions
Summary
Indeterminate lung nodules (6-15mm) are frequent findings in patients undergoing chest CT scanning, but adequate follow-up imaging is currently not in place to facilitate early detection, diagnosis and decision making regarding treatment. The introduction of long Field-Of-View PET/CT scanners could make a difference in this matter due to the substantial increase in sensitivity allowing optimal image quality. Whether this new technology could provide improved detection and follow-up of indeterminate lung nodules is what we aim to explore in this study.
Eligibility
Inclusion Criteria5
- able to give informed consent
- signed informed consent
- confirmed indeterminate lung nodule(s) of 6-15 mm in size on CT chest imaging
- routine 18F-FDG PET/CT performed
- scheduled for biopsy or resection of the lung nodules
Exclusion Criteria6
- claustrophobia
- pregnant or breastfeeding
- interval of at least 2 weeks between PET scan and last date of systemic anti-cancer therapy to reduce false-negative uptake in lesions
- radiation therapy of the target lung nodule(s)
- uncontrolled diabetes mellitus
- any medical condition potentially hampering conduction of the trial
Interventions
Patients will receive a single intravenous injection of 3 MBq/kg 18F-FDG
Patient will undergo 2 CT acquisitions and multiple PET emission scans.
Locations(1)
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NCT05463913