RecruitingNCT05470088

MRI Study of Subjects with ASD, Their Relatives and TD

Magnetic Resonance Imaging Neuroanatomical Study of Patients with an Autism Spectrum Disorder, Their Relatives and Typically Developing Subjects.

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Enrollment

1,000 participants

Start Date

Mar 13, 2022

Study Type

OBSERVATIONAL

Conditions

Autism Spectrum Disorder

Summary

This project is structured around a central study called "Study of genetic factors involved in autism and related conditions ("Genes and Autism" study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD. In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, relatives and controls. Our group has already performed several neuroanatomical studies of ASD. IWe recruited since 2010 more than 600 subjects (proponents, relatives and controls) to better understand the implication of brain abnormalities in ASD. This study involves specialized teams in neuroiamging based at INSERM, NeuroSpin (CEA), Robert Debré Hospital (APHP) and Pasteur Institute Our main objective is to identify structural, connectivity and functional peculiarities in subjects with ASD Secondary objectives include: * the identification of familial heritability patterns of ASD * correlate data obtained in brain imaging with genetic data * assess specificity and statistical reproducibility of the obtained results

Eligibility

Min Age: 24 Months

Inclusion Criteria27

for patients:
being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
having an ASD fulfilling DSM-5 diagnostic criteria (APA, 2012). Diagnosis will be done by a clinical expert, with the support of structured instruments (ADI-R, ADOS-2)
having at least 24 Months
being affiliated with the French health insurance
having signed the informed consent (by proposant or by legal tutors if the subject is <18 or under legal custody)
for relatives
being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
having at least 24 Months
being affiliated with the French health insurance
having signed the informed consent (by proposant or by legal tutors if the subject is <18 or under legal custody)
for controls
being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
having at least 24 Months
being affiliated with the French health insurance
having signed the informed consent (by proposant or by legal tutors if the subject is <18 or under legal custody)
for all subjects
severe mental retardation (IQ<35 or developmental age<18 months)
medical condition (either psychiatric or physical) not compatible with an inclusion
MRI counter indication
Current pregnancy or breastfeeding, assessed by questionnaire
Not willing to be informed of a brain abnormality diagnosed with MRI
for the relatives
*discovery of non filiation during the genetic analyses
for controls
Neurological history (except mental retardation)
Personal history of (checked with DIGS for Adults, Diagnostic Interview for Genetic Studies, Numberger et coll., 1994, or Kiddie SADS, Kiddie Schedule for Disorders and Schizophrenia for School Age Children, Orvaschel et coll., 1982): schizophrenia, addiction, bipolar disorder, recurrent depression (> 2 episodes lifetime), severe, not stabilized anxiety disorder, history of episodes of epilepsy, significant inflammatory disease of immunosuppressive medication

Exclusion Criteria2

for patients: ASD diagnosis not confirmed by assessments after the inclusion
for all subjects: discovery of a counter indication to MRI during the exam (e.g. claustrophobia)

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