RecruitingPhase 4NCT05471479

Activated CHARcoal in Poisoned Patient - Pilot Trial

CHARPP (Activated CHARcoal in Poisoned Patient): RCT Pilot Study


Sponsor

Laval University

Enrollment

100 participants

Start Date

Jul 16, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical pilot trial is to determine the feasibility of the clinical trial. Then the large-scale CHARPP will be conducted in order to determine the efficacity of activated charcoal as a treatment for acute poisoning in a diverse population of both adults and children suspected of ingesting toxic substances that activated charcoal can adsorb. The main questions it aims to answer are: * Can activated charcoal administered within a specific time frame prevent the progression of toxicity? * How does activated charcoal affect the length of stay in the hospital and the intensive care unit? Researchers will compare the intervention arm (receiving activated charcoal) to the control arm (receiving standard supportive care) to see if activated charcoal reduces hospital stay duration, ICU stay and improves overall patient outcomes. Participants will: * Be randomly assigned to either receive activated charcoal or standard supportive care. * Undergo assessments using standardized clinical scales such as the Poison Severity Score and, for children, the PELODS score. * Have their functional outcomes evaluated, such as the ability to return to their original residence without help and manage personal hygiene tasks independently. This structured approach will help clarify the role of activated charcoal in clinical toxicology and inform future treatment protocols.


Eligibility

Inclusion Criteria2

  • Adult and pediatric patients who presented to the hospital less than 6h after the ingestion of a potentially toxic dose of a carbo-adsorbable substance (substance adsorbed by activated charcoal ).
  • Patients who can receive the intervention within 6 hours of proven or suspected intoxication

Exclusion Criteria4

  • Patients requiring or who will likely require another gastro-intestinal decontamination method;
  • Patients who have contraindication to the use of activated charcoal;
  • Patients who ingested a substance with an entero-hepatic circulation requiring multi-dose AC;
  • Patients who have no clinical equipoise for the use of activated charcoal as per the attending physician.

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Interventions

DRUGActivated Charcoal

Activated charcoal

OTHERNo activated charcoal

No activated charcoal


Locations(1)

CHU de Québec - Université Laval

Québec, Quebec, Canada

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NCT05471479