RecruitingPhase 1Phase 2NCT05474729

Minocycline for Chronic Autoimmune Uveitis

The Efficacy and Safety of Minocycline for Chronic Autoimmune Uveitis


Sponsor

Sun Yat-sen University

Enrollment

10 participants

Start Date

Dec 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Autoimmune uveitis is one kind of non-infectious, sight-threatening, relapsing and severe ocular disease. Approximately 20%-25% autoimmune uveitis patients suffer from the dilemma of blindness for the chronic and persistent inflammatory state in the eyes, which results in continuous destroy in the structure of the eyes and gradually leads to irreversible damage on visual function. However, it shows limiting efficacy of current treatment including glucocorticoids, immunosuppressant and biologics for chronic autoimmune uveitis. Minocycline has been regarded to have anti-apoptosis and immunemodulatory function for decades and it has been illustrated to be beneficial in several neuro-degenerative and neuro-inflammatory diseases. This trial aims to investigate the efficacy and safety of minocycline for chronic autoimmune uveitis with retinal degenerative changes.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether minocycline (a common antibiotic with anti-inflammatory properties) can help treat chronic autoimmune uveitis — an inflammatory eye condition caused by the immune system attacking the eye, which can cause vision loss. **You may be eligible if...** - You have been diagnosed with an autoimmune eye disease (uveitis) that has caused decreased vision or structural changes in your retina - You are between 18 and 60 years old - You are able to attend follow-up visits **You may NOT be eligible if...** - You are allergic to minocycline or tetracycline antibiotics - You have abnormal liver, heart, kidney, or thyroid function - You are currently using steroids, immunosuppressants, or biologic medications - You are pregnant, breastfeeding, or planning to become pregnant - You are currently taking other medications for other conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGminocycline

minocycline capsule 100mg per day orally


Locations(1)

Zhongshan Ophthalmic Center

Guangzhou, Guangdong, China

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NCT05474729


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