HAIC With One-day FOLFOX vs. HAIC With Two-day FOLFOX for Unresectable HCC: a Non-inferiority Study

This study is comparing two versions of a chemotherapy treatment delivered directly into the liver's blood supply (called HAIC, or hepatic artery infusion chemotherapy) for people with liver cancer that cannot be surgically removed. One version takes one day to deliver; the other takes two days. The goal is to see if the shorter version works just as well. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with liver cancer (hepatocellular carcinoma, or HCC) that cannot be removed by surgery - Your liver function is relatively preserved (Child-Pugh class A or no cirrhosis) - Your blood counts, liver enzymes, and kidney function meet the required levels - You have at least one tumor that can be measured **You may NOT be eligible if...** - You have had significant gastrointestinal bleeding in the past 30 days - You have serious heart problems - You have signs of liver failure (like fluid build-up, bleeding, or confusion) - You have HIV or a history of organ transplant - You have known allergies to the study drugs Talk to your doctor to see if this trial is right for you.