RecruitingNot ApplicableNCT05479474

Platelet Rich Plasma Testis Treatment for Infertile Men

Platelet Rich Plasma Testis

Sponsor

Stanford University

Enrollment

10 participants

Start Date

Jan 18, 2023

Study Type

INTERVENTIONAL

Conditions

Male infertility Azoospermia Nonobstructive Azoospermia

Summary

Investigate the effect of intratesticular injection of autologous platelet rich plasma (PRP) on sperm retrieval rates and IVF outcomes in infertile men who already underwent a negative sperm retrieval. Currently, there is no alternative treatment after failed TESE. Prior series suggest that intratesticular PRP injections may improve TESE outcomes. We hope to determine whether PRP is an effective treatment for this patient population.

Eligibility

Sex: MALEMin Age: 18 Years

Inclusion Criteria1

Men over the age of 18 diagnosed with NOA and at least one failed TESE, negative mapping or negative biopsy

Exclusion Criteria1

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Interventions

BIOLOGICALPlatelet rich plasma

Patients will undergo a blood draw (12 tsp) to prepare the PRP infusion. The use of a centrifuge and an Arteriocyte Magellan kit are necessary for the PRP preparation. After injection of local anesthesia, PRP will be injected into each testicle. * On the third month after the testicular PRP procedure, a TESE will be performed * If the procedure is successful a new IVF cycle using the sperm procured from the procedure will be done.