A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)

This study is testing a new type of treatment called bacteriophage therapy (LBP-EC01) for uncomplicated urinary tract infections (UTIs) caused by antibiotic-resistant E. coli bacteria. Bacteriophages are tiny viruses that specifically target and kill bacteria — they don't harm human cells. The goal is to see if this treatment can clear drug-resistant UTIs where standard antibiotics may not work. You may be eligible if: • You are a woman aged 18 to 75 • You have had a UTI in the past 12 months caused by antibiotic-resistant E. coli • You currently have an active UTI with symptoms such as painful urination, frequent urination, urgency, or pelvic pain • You can provide a urine sample for testing • You are willing to stop other UTI antibiotics for the first 10 days of the study You may NOT be eligible if: • You have signs of a complicated or severe infection (fever above 38°C, chills, or other systemic symptoms) • You are pregnant or breastfeeding • You have an indwelling urinary catheter or significant urinary tract abnormalities • You have poorly controlled diabetes (HbA1c above 8) or severely reduced kidney function • You are immunocompromised • You have had symptoms for more than 5 days before screening • You have used another antibiotic for this UTI in the last 5 days (unless resistant) Talk to your doctor to see if this trial is right for you.