JAB-2485 Activity in Adult Patients With Advanced Solid Tumors

This study is testing a new investigational drug called JAB-2485 in adults with advanced solid tumors that have not responded to standard treatments. The drug targets a specific protein pathway that some cancers rely on to grow. **You may be eligible if...** - You are 18 or older with advanced or metastatic solid tumor cancer - Your cancer has stopped responding to existing treatments or you cannot tolerate them - You are in good general health (ECOG 0–1) - Your cancer has at least one measurable lesion on scans - You are able to swallow oral medication - You can provide an archived tumor tissue sample - Your organ function (liver, kidney, blood counts) meets required levels **You may NOT be eligible if...** - You have active, growing cancer in the brain or spinal fluid - You have active hepatitis B, hepatitis C, or HIV - You have a serious uncontrolled medical condition - Your heart pumping function (ejection fraction) is 50% or less - You have a significant heart rhythm abnormality (QTcF prolongation) Talk to your doctor to see if this trial is right for you.