Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
Targeted Spinal Cord Plasticity for Alleviating SCI-related Neuropathic Pain
Medical University of South Carolina
15 participants
Mar 27, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).
Eligibility
Inclusion Criteria5
- neurologically stable (>1 year post SCI)
- medical clearance to participate
- ability to stand with or without an assistive device for at least 3 minutes at a time
- expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted)
- For participants with neuropathic pain, the area of neuropathic pain must include lower leg.
Exclusion Criteria8
- motoneuron injury
- known cardiac condition
- medically unstable condition (incl. pregnancy)
- cognitive impairment
- uncontrolled peripheral neuropathy
- frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment
- daily use of electrical stimulation to the leg
- complete lack of cutaneous sensation around foot.
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Interventions
This is a training intervention in which people with a spinal cord injury are trained to change (increase or decrease) the activity of a certain spinal reflex. By changing this reflex, it is hypothesized that individuals can reduce pain due to spinal cord injury.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05492188