Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

This pilot study is comparing two different blood sample collection methods to detect cancer DNA in the bloodstream (called "liquid biopsy") in patients with liver, bile duct, or pancreatic cancers. The goal is to find out which collection method gives better results during a biopsy procedure. **You may be eligible if...** - You are 18 or older and have or are being evaluated for liver, bile duct, or pancreatic cancer - You are scheduled for an image-guided biopsy of a lesion - You are able to lie still during the procedure **You may NOT be eligible if...** - You have a bleeding disorder that cannot be corrected - Your platelet count is very low or your blood clotting is abnormal - You weigh more than 375 pounds (equipment weight limit) - You have moderate to severe fluid buildup in the abdomen (ascites) Talk to your doctor to see if this trial is right for you.