RecruitingNCT05498064

A Real World Study of Ensartinib in Advanced ALK-positive NSCLC

A Real World Study of Ensartinib in Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)


Sponsor

Peking Union Medical College Hospital

Enrollment

490 participants

Start Date

May 13, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

The primary objective of this study is to evaluate the efficacy and safety of Ensartinib in advanced ALK-positive non-small cell lung cancer, and the mechanisms of population pharmacokinetics and resistance to Ensartinib.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This real-world study is following patients with advanced lung cancer that has a specific genetic change called "ALK-positive" who are being treated with a drug called ensartinib. The goal is to understand how well the drug works and what side effects occur outside of a controlled clinical trial setting. **You may be eligible if...** - You have advanced (stage IIIB or IV) non-small cell lung cancer with an ALK-positive mutation - Your cancer has progressed during or after a prior ALK-targeted therapy - You have an acceptable level of physical functioning (ECOG 0–2) - Your disease may benefit from radiation to certain areas (bone, lung, adrenal) **You may NOT be eligible if...** - You have not had prior ALK-targeted treatment - Your general health or lab results are not adequate for treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEnsartinib

Ensartinib 225 mg administered once daily orally


Locations(1)

Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

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NCT05498064


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