A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
A Randomized, Double-Blind, Phase 3 Trial of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated, Locally Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
Mirati Therapeutics Inc.
630 participants
Apr 24, 2025
INTERVENTIONAL
Summary
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation
Eligibility
Inclusion Criteria7
- Histologically or cytologically confirmed diagnosis of non-squamous NSCLC with evidence of KRAS G12C mutation via tumor sample and/or circulating tumor deoxyribonucleic acid (ctDNA).
- Locally advanced or metastatic disease.
- Measurable disease via computed tomography (CT) or magnetic resonance imaging (MRI) per RECIST v1.1 criteria of at least 1 lesion.
- No prior systemic anti-cancer therapy given for advanced or metastatic disease.
- Not a candidate for definitive therapy (eg, chemoradiation or complete surgical resection).
- Participants with brain metastases are eligible for enrollment, including those with untreated brain metastases. Brain metastases must be asymptomatic and not in need of immediate local therapy. Any untreated brain metastases must be ≤ 20 mm in diameter.
- Any PD-L1 expression (0 to 100%) as determined by VENTANA PD-L1 (SP263) assay, Agilent PD-L1 IHC 22C3 pharmDx, or Agilent PD-L1 IHC 28-8 pharmDx.
Exclusion Criteria6
- Participants with an active autoimmune or inflammatory disease requiring systemic treatment within 2 years.
- Uncontrolled or significant cardiovascular conditions within 6 months prior to enrollment that are ongoing or with risk of recurrence.
- Inadequate bone marrow or liver function or electrocardiogram (ECG) abnormalities.
- Ongoing treatment with concomitant medication known to cause prolonged QTc interval and that cannot be switched to alternative treatment prior to study entry.
- Treatment targeting KRAS G12C mutation (eg, sotorasib, adagrasib) in any setting.
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration.
Interventions
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Specified dose on specified days
Locations(337)
Local Institution - 0347
Birmingham, Alabama, United States
Local Institution - 0686
Springdale, Arkansas, United States
Local Institution - 0581
Fullerton, California, United States
Local Institution - 0682
Loma Linda, California, United States
Local Institution - 0202
Long Beach, California, United States
Local Institution - 0623
Santa Barbara, California, United States
Local Institution - 0442
Denver, Colorado, United States
Local Institution - 0052
Jacksonville, Florida, United States
Local Institution - 0680
Ocala, Florida, United States
Local Institution - 0679
Orange City, Florida, United States
Local Institution - 0621
Palm Bay, Florida, United States
Florida Clinical Trials Group.
Tamarac, Florida, United States
Local Institution - 0647
Tampa, Florida, United States
Local Institution - 0031
Marietta, Georgia, United States
Local Institution - 0665
Arlington Heights, Illinois, United States
Local Institution - 0676
Chicago, Illinois, United States
Local Institution - 0683
Springfield, Illinois, United States
Local Institution - 0684
Fort Wayne, Indiana, United States
Local Institution - 0423
Munster, Indiana, United States
Local Institution - 0366
Edgewood, Kentucky, United States
Local Institution - 0566
Louisville, Kentucky, United States
Local Institution - 0644
Shreveport, Louisiana, United States
Local Institution - 0385
Columbia, Maryland, United States
Local Institution - 0019
Boston, Massachusetts, United States
Local Institution - 0293
Detroit, Michigan, United States
Local Institution - 0685
Fenton, Missouri, United States
Local Institution - 0678
Cooperstown, New York, United States
Local Institution - 0634
Schenectady, New York, United States
Local Institution - 0618
White Plains, New York, United States
Local Institution - 0624
Asheville, North Carolina, United States
Local Institution - 0672
Salisbury, North Carolina, United States
Local Institution - 0688
Easton, Pennsylvania, United States
Local Institution - 0657
York, Pennsylvania, United States
Local Institution - 0681
Greenville, South Carolina, United States
Local Institution - 0658
Greenville, South Carolina, United States
Local Institution - 0020
Nashville, Tennessee, United States
Local Institution - 0652
Laredo, Texas, United States
Local Institution - 0622
San Antonio, Texas, United States
Instituto Alexander Fleming
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
IDIM - Instituto de Investigaciones Metabólicas
Ciudad de Buenos Aires, Buenos Aires, Argentina
Hospital Universitario Austral
Pilar, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
ABB, Buenos Aires F.D., Argentina
Local Institution - 0571
Buenos Aires, Buenos Aires F.D., Argentina
Clinica Adventista Belgrano
CABA, Buenos Aires F.D., Argentina
Sanatorio Plaza
Rosario, Santa Fe Province, Argentina
Canberra Hospital
Canberra, Australian Capital Territory, Australia
Tamworth Hospital
North Tamworth, New South Wales, Australia
Orange Hospital
Orange, New South Wales, Australia
Princess Alexandra Hospital
Brisbane, Queensland, Australia
Lyell McEwin Hospital
Elizabeth Vale, South Australia, Australia
Frankston Hospital
Frankston, Victoria, Australia
Northern Hospital
Melbourne, Victoria, Australia
Latrobe Regional Health
Traralgon, Victoria, Australia
Joondalup Health Campus
Joondalup, Western Australia, Australia
Medizinische Universität Graz
Graz, Styria, Austria
Klinikum Wels-Grieskirchen GmbH
Wels, Upper Austria, Austria
Kepler Universitätsklinikum
Linz, Austria
Medizinische Universität Wien
Vienna, Austria
Local Institution - 0673
Vienna, Austria
UZ Brussel
Brussels, Bruxelles-Capitale, Région de, Belgium
Cliniques universitaires Saint-Luc
Brussels, Bruxelles-Capitale, Région de, Belgium
Jessa Ziekenhuis
Hasselt, Limburg, Belgium
AZ Maria Middelares
Ghent, Oost-Vlaanderen, Belgium
UZ Leuven
Leuven, Vlaams-Brabant, Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Belgium
CEDOES
Vitória, Espírito Santo, Brazil
Nucleo de Oncologia da Bahia
Salvador, Estado de Bahia, Brazil
Cetus Oncologia - Unidade Belo Horizonte
Belo Horizonte, Minas Gerais, Brazil
ONCOSITE - Centro de Pesquisa Clinica em Oncologia
Ijuí, Rio Grande do Sul, Brazil
Hospital São Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, Brazil
Instituto de Oncologia Saint Gallen
Santa Cruz do Sul, Rio Grande do Sul, Brazil
Hospital de Amor Amazônia
Porto Velho, Rondônia, Brazil
Clínica de Oncologia Reichow
Blumenau, Santa Catarina, Brazil
Clínica de Neoplasias Litoral
Itajaí, Santa Catarina, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, São Paulo, Brazil
Advanze Pesquisa
São Carlos, São Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
São José do Rio Preto, São Paulo, Brazil
A. C. Camargo Cancer Center
São Paulo, São Paulo, Brazil
Instituto Nacional de Câncer - INCA
Rio de Janeiro, Brazil
Local Institution - 0258
São Paulo, Brazil
MBAL Uni Hospital
Panagyurishte, Pazardzhik, Bulgaria
Multiprofile Hospital for Active Treatment Serdika EOOD
Sofia, Sofia (stolitsa), Bulgaria
Complex Oncology Center - Ruse EOOD
Rousse, Bulgaria
Trakia Hospital
Stara Zagora, Bulgaria
Local Institution - 0074
Halifax, Nova Scotia, Canada
Local Institution - 0559
Montreal, Quebec, Canada
Bradfordhill
Recoleta, Santiago Metropolitan, Chile
FALP
Santiago, Santiago Metropolitan, Chile
The First Afflilated Hospital of Bengbu Medical College
Bengbu, Anhui, China
Anhui Provincial Hospital
Hefei, Anhui, China
Beijing Cancer hospital
Beijing, Beijing Municipality, China
Beijing Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Beijing Chest Hospital,Capital Medical University
Beijing, Beijing Municipality, China
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China
Fujian Medical University Union Hospital
Fuzhou Fujian, Fujian, China
The First Affiliated hospital of Xiamen University
Xiamen, Fujian, China
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Cancer Hospital of Shantou University Medical College
Shantou, Guangdong, China
Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center
Shenzhen, Guangdong, China
ShenZhen People's Hospital
Shenzhen, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital
Nanning, Guangxi, China
Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Nanyang City Center Hospital
Nanyang, Henan, China
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, Henan, China
Tongji Hospital Tongji Medical,Science & Technology
Wuhan, Hubei, China
Hunan Cancer Hospital
Changsha, Hunan, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China
The First Affiliated Hospital Of Soochow University
Suzhou, Jiangsu, China
Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
The First Hospital of Jilin University
Changchun, Jilin, China
The First Hospital of China Medical University
Shenyang, Liaoning, China
Shengjing Hospital of China Medical University
Shenyang, Liaoning, China
Liaoning Cancer Hospital
Shenyang, Liaoning, China
Shandong Cancer Hospital
Jinan, Shandong, China
LinYi Cancer Hospital
Linyi, Shandong, China
Local Institution - 0470
Shanghai, Shanghai Municipality, China
Local Institution - 0381
Shanghai, Shanghai Municipality, China
Shanghai East Hospital
Shanghai, Shanghai Municipality, China
Shanxi Cancer Hospital
Taiyuan, Shanxi, China
Sichuan Cancer hospital
Chengdu, Sichuan, China
West China Hospital, Sichuan University
Chengdu, Sichuan, China
Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China
The first Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Taizhou Hospital of Zhejiang Province
Taizhou, Zhejiang, China
Clinica Somer
Rionegro, Antioquia, Colombia
Local Institution - 0191
Puerto Colombia, Atlántico, Colombia
Local Institution - 0189
Bogotá, Bogota D.C., Colombia
Sociedad De Oncología y Hematología Del Cesar SAS
Valledupar, Cesar Department, Colombia
Instituto Médico de Alta Tecnología S.A.S - IMAT S.A.S
Montería, COR, Colombia
Local Institution - 0671
Bogota, Cundinamarca, Colombia
Fundación Cardiovascular de Colombia
Floridablanca, Santander Department, Colombia
Fundación Valle del Lili
Cali, Valle del Cauca Department, Colombia
Clinica Medellin S.A
Medellín, Colombia
Opća bolnica Dubrovnik
Dubrovnik, Dubrovnik-Neretva County, Croatia
Poliklinika MEDICO - Rijeka
Rijeka, Primorje-Gorski Kotar County, Croatia
Klinički Bolnički Centar Split
Split, Split-Dalmatia County, Croatia
Local Institution - 0567
Osijek, Croatia
Local Institution - 0585
Zagreb, Croatia
Local Institution - 0159
Mulhouse, Alsace, France
Centre François Baclesse
Caen, Calvados, France
Centre Georges François Leclerc
Dijon, Côte-d'Or, France
CHRU de Brest
Brest, Finistère, France
Institut Régional du Cancer Montpellier
Montpellier, Hérault, France
Chu Grenoble Alpes
La Tronche, Isère, France
Centre Hospitalier Universitaire d'Angers
Angers, Maine-et-Loire, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France
Institut Paoli-Calmettes
Marseille, Provence-Alpes-Côte d'Azur Region, France
CHU d'Amiens-Picardie - Hôpital Sud
Amiens, Somme, France
Gustave Roussy
Villejuif, Val-de-Marne, France
Hôpital Ambroise Paré
Boulogne-Billancourt, France
Chu Gabriel Montpied
Clermont-Ferrand, France
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
Limoges, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
Marseille, France
Local Institution - 0133
Paris, France
Hopitaux Universitaires Paris Centre-Hopital Cochin
Paris, France
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Saint-Herblain, France
Klinikum Esslingen
Esslingen am Neckar, Baden-Wurttemberg, Germany
Bundeswehrkrankenhaus Ulm
Ulm, Baden-Wurttemberg, Germany
Hadassah Medical Center
Jerusalem, Jerusalem, Israel
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
München, Bavaria, Germany
Centrum für Hämatologie und Onkologie Bethanien
Frankfurt am Main, Hesse, Germany
UKGM Gießen/Marburg
Giessen, Hesse, Germany
Praxis Onkologie am Raschplatz
Hanover, Lower Saxony, Germany
Pius Hospital Oldenburg
Oldenburg, Lower Saxony, Germany
Klinikum Köln-Merheim
Cologne, North Rhine-Westphalia, Germany
Evangelisches Krankenhaus Herne - Eickel
Herne, North Rhine-Westphalia, Germany
Universitätsklinikum Halle
Halle, Saxony-Anhalt, Germany
Malteser Krankenhaus St. Franziskus-Hospital
Flensburg, Schleswig-Holstein, Germany
SRH Wald-Klinikum Gera GmbH
Gera, Thuringia, Germany
Universitätsklinikum Jena
Jena, Thuringia, Germany
Vivantes Klinikum Neukölln
Berlin, Germany
Evangelische Lungenklinik Berlin
Berlin, Germany
Local Institution - 0675
Halle, Germany
Lungenklinik Hemer
Hemer, Germany
Klinikum Stuttgart - Katharinenhospital
Stuttgart, Germany
Universitaetsklinikum Wuerzburg
Würzburg, Germany
Errikos Dunant Hospital Center
Athens, Attikí, Greece
Thoracic General Hospital of Athens "I Sotiria"
Athens, Attikí, Greece
University General Hospital of Larissa
Larissa, Thessalía, Greece
Queen Mary Hospital
Hksar, Hong Kong
Queen Mary Hospital
Hksar, Hong Kong
Local Institution - 0144
Gyöngyös - Mátraháza, Heves County, Hungary
Local Institution - 0157
Tatabánya, Komárom-Esztergom, Hungary
Farkasgyepui Tudogyogyintezet
Farkasgyepű, Veszprém megye, Hungary
Semmelweis Egyetem
Budapest, Hungary
Országos Korányi Pulmonológiai Intézet
Budapest, Hungary
Petz Aladar Egyetemi Oktato Korhaz
Győr, Hungary
Local Institution - 0222
Visakhapatnam, Andhra Pradesh, India
Local Institution - 0136
Ahmedabad, Gujarat, India
Local Institution - 0230
Ahmedabad, Gujarat, India
Local Institution - 0155
Thiruvananthapuram, Kerala, India
Local Institution - 0154
Mumbai, Maharashtra, India
Local Institution - 0312
New Delhi, National Capital Territory of Delhi, India
Local Institution - 0511
New Delhi, National Capital Territory of Delhi, India
Local Institution - 0135
New Delhi, National Capital Territory of Delhi, India
Local Institution - 0226
Bhubaneswar, Odisha, India
Local Institution - 0224
Madurai, Tamil Nadu, India
Local Institution - 0663
Hyderabad, Telangana, India
Local Institution - 0153
Varanasi, Uttar Pradesh, India
Local Institution - 0161
Howrah, West Bengal, India
Local Institution - 0221
Kolkata, West Bengal, India
Local Institution - 0661
Hyderabad, India
Cork University Hospital
Cork, Ireland
Mater Private Hospital - Dublin
Dublin, Ireland
St. James's Hospital
Dublin, Ireland
UCD School of Medicine Beacon Hospital
Dublin, Ireland
Beaumont Hospital, Dublin
Dublin, Ireland
Rabin Medical Center
Petah Tikva, Central District, Israel
Sheba Medical Center
Ramat Gan, Central District, Israel
Yitzhak Shamir Medical Center
Ẕerifin, Central District, Israel
Carmel Hospital
Haifa, Ḥeifā, Israel
Instituto Tumori Giovanni Paolo II
Bari, Apulia, Italy
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, Italy
A.O.R.N. Ospedale dei Colli - Monaldi V.
Naples, Napoli, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, Italy
Istituto Nazionale Tumori Regina Elena
Rome, Roma, Italy
Azienda Ospedaliera Universitaria Careggi
Florence, Tuscany, Italy
Ospedale San Martino
Genova, Italy
Istituto Oncologico Veneto IRCCS
Padua, Italy
Azienda Ospedaliero Universitaria di Parma
Parma, Italy
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Local Institution - 0556
Varese, Italy
Local Institution - 0607
Nagoya, Aichi-ken, Japan
Local Institution - 0305
Nagoya, Aichi-ken, Japan
Local Institution - 0298
Sapporo, Hokkaido, Japan
Local Institution - 0304
Kanazawa, Ishikawa-ken, Japan
Local Institution - 0302
Sagamihara, Kanagawa, Japan
Local Institution - 0369
Yokohama, Kanagawa, Japan
Local Institution - 0301
Sendai, Miyagi, Japan
Local Institution - 0306
Kashihara, Nara, Japan
Local Institution - 0368
Kurashiki, Okayama-ken, Japan
Local Institution - 0642
Hirakata, Osaka, Japan
Local Institution - 0303
Hidaka, Saitama, Japan
Local Institution - 0300
Ina-machi, Saitama, Japan
Hamamatsu University Hospital
Hamamatsu, Shizuoka, Japan
Local Institution - 0299
Shimotsuga, Tochigi, Japan
Local Institution - 0674
Bunkyo Ku, Tokyo, Japan
Local Institution - 0343
Toyoma, Toyama, Japan
Local Institution - 0542
Iwakuni, Yamaguchi, Japan
Local Institution - 0307
Akashi, Japan
Local Institution - 0346
Aomori, Japan
Local Institution - 0310
Fukuoka, Japan
Local Institution - 0367
Fukushima, Japan
Local Institution - 0308
Kumamoto, Japan
Local Institution - 0687
Nagasaki, Japan
Osaka City General Hospital
Osaka, Japan
Osaka International Cancer Institute
Osaka, Japan
Centro de Infusion E Investigacion Oncologia de Saltillo S.C.
Saltillo, Coahuila, Mexico
Local Institution - 0176
Mexico City, DIF, Mexico
Local Institution - 0579
Pachuca, Hidalgo, Mexico
Hospital Civil Fray Antonio Alcalde
Guadalajara, Jalisco, Mexico
Axis Heilsa S. de R.L. de C.V.
Monterrey, Nuevo León, Mexico
Local Institution - 0175
Chihuahua City, Mexico
Unidad Médica Onco-hematológica
Puebla City, Mexico
Local Institution - 0638
Puebla City, Mexico
Local Institution - 0180
Veracruz, Mexico
Maastricht UMC+
Maastricht, Limburg, Netherlands
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
Amsterdam, North Holland, Netherlands
Med-Polonia Sp. z o. o.
Poznan, Greater Poland Voivodeship, Poland
Szpital Specjalistyczny im. Henryka Klimontowicza
Gorlice, Lesser Poland Voivodeship, Poland
Pratia MCM Krakow
Krakow, Lesser Poland Voivodeship, Poland
Dolnośląskie Centrum Onkologii, Pulmonologii i Hematologii
Wroclaw, Lower Silesian Voivodeship, Poland
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie
Lublin, Lublin Voivodeship, Poland
Centrum Onkologii im. Prof. Franciszka Lukaszczyka
Bydgoszcz, Poland
Pratia Onkologia Katowice
Katowice, Poland
Szpital Specjalistyczny w Prabutach Spolka z o.o.
Prabuty, Poland
Instituto Português de Oncologia de Lisboa Francisco Gentil
Lisbon, Lisbon District, Portugal
Instituto Portugês de Oncologia de Coimbra Francisco Gentil
Coimbra, Portugal
Centro Hospitalar do Porto - Hospital de Santo António
Porto, Portugal
SC Memorial Healthcare International SRL
Bucharest, București, Romania
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
Bucharest, București, Romania
Cardiomed SRL Cluj-Napoca
Cluj-Napoca, Cluj, Romania
SC Radiotherapy Center Cluj SRL
Florești, Cluj, Romania
Ovidius Clinical Hospital OCH
Ovidiu, Constanța County, Romania
Centrul de Oncologie "Sfântul Nectarie"
Craiova, Dolj, Romania
Cabinet Medical Oncomed
Timișoara, Timiș County, Romania
Institutul Oncologic Cluj
Cluj-Napoca, Romania
Institutul Oncologic Cluj
Cluj-Napoca, Romania
Affidea Constanța
Constanța, Romania
S.C. Centrul de Oncologie Euroclinic S.R.L.
Iași, Romania
Institutul Regional de Oncologie
Iași, Romania
Spitalul Municipal Schuller Ploiești
Ploieşti, Romania
Local Institution - 0614
Jeddah, Makkah Al Mukarramah, Saudi Arabia
Local Institution - 0602
Riyadh, Saudi Arabia
Local Institution - 0562
Riyadh, Saudi Arabia
Chungbuk National University Hospital
Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea
Gachon University Gil Medical Center
Namdong-gu, Incheon-gwangyeoksi [Incheon], South Korea
Pusan National University Yangsan Hospital
Yangsan, Kyǒngsangnam-do, South Korea
Pusan National University Hospital
Busan, Pusan-Kwangyǒkshi, South Korea
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Konkuk University Medical Center
Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Local Institution - 0248
Seoul, Seoul-teukbyeolsi [Seoul], South Korea
Korea University Guro Hospital
Seoul, Seoul-teukbyeolsi [Seoul], South Korea
CHUAC-Hospital Teresa Herrera
A Coruña, A Coruña [La Coruña], Spain
CHUS - Hospital Clinico Universitario
Santiago de Compostela, A Coruña [La Coruña], Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], Spain
Local Institution - 0497
Hospitalet, Barcelona [Barcelona], Spain
Local Institution - 0505
Barcelona, Catalunya [Cataluña], Spain
Hospital Son Llàtzer
Palma, Illes Balears [Islas Baleares], Spain
Hospital General Universitario Gregorio Marañon
Madrid, Madrid, Comunidad de, Spain
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, Spain
Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, Comunidad de, Spain
CHUVI- Hospital Alvaro Cunqueiro
Pontevedra, Pontevedra [Pontevedra], Spain
Hospital Arnau de Vilanova
Valencia, València, Spain
Hospital Clinico San Carlos
Madrid, Spain
H.R.U Málaga - Hospital General
Málaga, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Local Institution - 0495
Valencia, Spain
Kantonsspital Münsterlingen - Spital Thurgau AG
Münsterlingen, Switzerland
Chi Mei Hospital - Liouying Branch
Tainan, Tainan, Taiwan
Tri-Service General Hospital
Taipei City, Taipei, Taiwan
Taipei Medical University Shuang Ho Hospital
New Taipei City, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Chulalongkorn University
Bangkok, Bangkok, Thailand
Faculty of Medicine - Khon Kaen University
Muang, Changwat Khon Kaen, Thailand
Songklanagarind hospital
Hat Yai, Changwat Songkhla, Thailand
Local Institution - 0199
Izmir, Karsiyaka, İzmir, Turkey (Türkiye)
Local Institution - 0197
Adana, Turkey (Türkiye)
Hacettepe Universite Hastaneleri
Ankara, Turkey (Türkiye)
Ankara University Health Practice and Research Hospitals
Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi
Ankara, Turkey (Türkiye)
Local Institution - 0550
Istanbul, Turkey (Türkiye)
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
Istanbul, Turkey (Türkiye)
Local Institution - 0200
Izmir, Turkey (Türkiye)
University College London Hospital
London, London, City of, United Kingdom
Guy's & St Thomas' NHS Foundation Trust
London, London, City of, United Kingdom
Heartlands Hospital
Birmingham, United Kingdom
Local Institution - 0545
Guildford, United Kingdom
The Royal Surrey County Hospital
Guildford, United Kingdom
Local Institution - 0093
Manchester, United Kingdom
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06875310