RecruitingNCT05498584

Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study

Sponsor

Chang Gung Memorial Hospital

Enrollment

130 participants

Start Date

Aug 25, 2022

Study Type

OBSERVATIONAL

Conditions

Heart Failure; With Decompensation

Summary

A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study. The investigators will further investigate the predictors including LOXl2, cardiac MRI, and endothelial function that will benefit from a successful CR.

Eligibility

Min Age: 20 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating a protein called LOXL2 that may contribute to scarring (fibrosis) of the heart after heart failure. Researchers want to understand whether measuring this protein can help predict outcomes in heart failure patients and guide future treatments. **You may be eligible if...** - You are 20 or older and currently hospitalized for heart failure - Your heart failure is classified as moderate to severe (NYHA class II–IV) - Your heart pumping function (ejection fraction) is 40% or less - Your BNP or NT-proBNP blood levels are elevated **You may NOT be eligible if...** - Your expected survival is less than 6 months - You have been bedridden for more than 3 months - You cannot participate in exercise testing due to physical or musculoskeletal problems - You have severe valve disease, are on a ventilator, or are in a terminal stage Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALexercise based cardiac rehabilitation

The types of exercise are treadmill walking/walking-jogging/jogging, ergometer cycling, stair climbing, or elliptical machine training. The training intensity is gradually increased fortnightly to reach the targeted Borg's rate of perceived exertion (RPE) of 12-14. The training duration is 40 minutes, which included 5-10 minutes of warm-up and cool-down exercises. The training frequency is three sessions per week, with 36 sessions concluding a complete course.

Locations(1)

Chang Gung Memorial Hospital Heart Failure Center

Kaohsiung City, Taiwan

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