RecruitingNCT05498584

Targeting LOXL2 and Cardiac Fibrosis for Post-acute Heart Failure Treatment- A Prospective Study

Sponsor

Chang Gung Memorial Hospital

Enrollment

130 participants

Start Date

Aug 25, 2022

Study Type

OBSERVATIONAL

Conditions

Heart Failure; With Decompensation

Summary

A previous study demonstrated that a multidisciplinary cardiac rehabilitation (CR) program was associated with reduced medium- to long-term all-cause mortality in a retrospective propensity score-matched study. The investigators will further investigate the predictors including LOXl2, cardiac MRI, and endothelial function that will benefit from a successful CR.

Eligibility

Min Age: 20 YearsMax Age: 100 Years

Inclusion Criteria4

Patients must give written informed consent before any assessment is performed.
Inpatients \>= 20 years of age, male or female.
Patients with a diagnosis of heart failure New York Heart Association (NYHA) class II-IV with BNP \>=100 pg/mL or NT-porBNP \>= 400 pg/mL ( \>= 900 pg/mL if concomitant atrial fibrillation)
Left ventricular ejection fraction \<= 40% by echocardiography or other methods

Exclusion Criteria8

Estimated survival time \< 6 months
Long-term bedridden for more than 3 months
Cannot tolerate exercise test due to muscular skeletal disorder.
Cannot cooperate all functional studies
Ventilator dependent
Terminal heart status
Family rejects to participate in this project
Primary severe valvular heart disease

Interventions

BEHAVIORALexercise based cardiac rehabilitation

The types of exercise are treadmill walking/walking-jogging/jogging, ergometer cycling, stair climbing, or elliptical machine training. The training intensity is gradually increased fortnightly to reach the targeted Borg's rate of perceived exertion (RPE) of 12-14. The training duration is 40 minutes, which included 5-10 minutes of warm-up and cool-down exercises. The training frequency is three sessions per week, with 36 sessions concluding a complete course.